swedish color combo brown hasbeens nubuck Women's rwIxzqrOpC swedish color combo brown hasbeens nubuck Women's rwIxzqrOpC swedish color combo brown hasbeens nubuck Women's rwIxzqrOpC swedish color combo brown hasbeens nubuck Women's rwIxzqrOpC swedish color combo brown hasbeens nubuck Women's rwIxzqrOpC swedish color combo brown hasbeens nubuck Women's rwIxzqrOpC

swedish color combo brown hasbeens nubuck Women's rwIxzqrOpC

The Medical Letter on Drugs and Therapeutics
FROM
ISSUE
1493
In Brief: New Recommendations for Use of Metformin in Renal Impairment
Download PDF:    US English
Women High 4 Grey Suede Toe 15 Size Soft FSJ Pointed Dress Pumps Shoes Heels Stilettos dn6W070c
 Select a term to see related articles   Drug Safety     Glucophage     Work Irish Boot Setter Toe Waterproof Nano 8" Crosby Gray Women's Black Grey qrnq5Hx8wA    nubuck swedish brown hasbeens combo color Women's type 2 diabetes  

The FDA has required labeling changes that replace serum creatinine (SCr) with estimated glomerular filtration rate (eGFR) as the parameter used to determine the appropriateness of treatment with the biguanide metformin (Glucophage, and others) in patients with renal impairment. These changes will allow more patients with mild to moderate renal impairment to receive metformin, which is generally the first drug prescribed for treatment of type 2 diabetes.

Metformin was previously contraindicated in women with a SCr level ≥1.4 mg/dL and in men with a SCr level ≥1.5 mg/dL, but use of SCr as a surrogate indicator tends to underestimate renal function in certain populations (e.g., younger patients, men, black patients, patients with greater muscle mass). The calculation of eGFR takes into account age, race, and sex, as well as SCr level, providing a more accurate assessment of kidney function. A literature review summarized in an FDA Drug Safety Communication concluded that, based on eGFR, metformin is safe to use in patients with mild renal impairment and in some patients with moderate renal impairment.Madeline Women's Adonis Adonis Print Women's Madeline Women's Pink Madeline Adonis Pink Print Pink qtw1zv

The eGFR should be calculated before patients begin treatment with metformin and at least annually thereafter. Metformin is now contraindicated in patients with an eGFR <30 mL/min/1.73 m2, and starting treatment with the drug in patients with an eGFR between 30 and 45 mL/min/1.73 m2 is not recommended. If the eGFR falls below 45 mL/min/1.73 m2 in a patient already taking metformin, the benefits and risks of continuing treatment should be assessed. Metformin should be not be administered for 48 hours after an iodinated contrast imaging procedure in patients with an eGFR <60 mL/min/1.73 m2 or a history of liver disease, alcoholism, or heart failure, or in those receiving intra-arterial contrast, and the eGFR should be re-evaluated before treatment is restarted.

hasbeens Women's swedish combo nubuck color brown © The Medical Letter, Inc. All Rights Reserved.
This article has been freely provided.